Emerging Designs and Developments of Biodegradable Metallic Alloys for Biomedical Applications
Keywords:
Biodegradable, alloys, magnesium-based systems, biomedical applications.Abstract
Biodegradable metal alloys are new classes of biomaterials that can offer mechanical support that will dissolve in the human body after the therapeutic regime. Alloy implants made from magnesium, zinc and iron will have more advantages than conventional ones as they do not present long term side effects. Also, they will not require removal. This study explains recent findings, designs and constructions of metal alloys that are highly biodegradable for temporary purposes. Welders of materials beneath human skin must certainly be familiar with each of these properties: corrosion house, integrity, biocompatibility. Research shows that your body responds quickly to natural elements, helping performance and recovery. We include antioxidants and growth problem solvers. We have updated the breakdown systems and your human response. Apart from that, new applications can arise in injections, arthritis, and heart and tissue repair. All of these methods require careful timing to function correctly. While having known alloys presents great issues for material outcome and "degradation" of parts, the challenges continue. Hospitals can use biodegradable metallic alloys, which allow for the use of advanced materials for the transfer from lab study to common practice.
References
Zhu Y, Liu Y, Wu L, Yang Q. Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis. Front Mater. 2023;10:1265977. doi:10.3389/fmats.2023.1265977.
Sort J. Special feature: permanent and long-term biodegradable biomaterials. Appl Sci. 2022;12(24):12874. doi:10.3390/app122412874.
Yang H, Lin W, Zheng Y. Advances and perspective on the translational medicine of biodegradable metals. Biomater Transl. 2021;2(3):177-188. doi:10.12336/biomatertransl.2021.03.002.
Thomas K, Zafar MN, Pitt WG, Husseini GA. Biodegradable magnesium alloys for biomedical implants: properties, challenges, and surface modifications with a focus on orthopedic fixation repair. Appl Sci. 2023;14(1):10. doi:10.3390/app14010010.
Vinogradov A, Merson ED, Myagkikh P, Linderov M, Brilevsky A, Merson D. Attaining high functional performance in biodegradable Mg-alloys: an overview of challenges and prospects for the Mg-Zn-Ca system. Materials. 2023;16(3):1324. doi:10.3390/ma16031324.
Zohdy KM, El-Sherif RM, El-Shamy AM. Effect of pH fluctuations on the biodegradability of nanocomposite Mg-alloy in simulated bodily fluids. Chem Pap. 2023;77(3):1317-1328. doi:10.1007/s11696-022-02544-y.
Radwan-Pragłowska J, Legutko K, Janus Ł, Sierkowska-Byczek A, Kuźmiak K, Radwan-Pragłowska N. Electrochemical surface modification of fully biodegradable Mg-based biomaterials as a sustainable alternative to non-resorbable bone implants. Appl Sci. 2025;15(5):2492. doi:10.3390/app15052492.
Taghipour S, Tahami FV, Allahverdizadeh A. Optimum design of a biodegradable implant for femoral shaft fracture fixation using finite element method. Res Square. 2024. doi:10.21203/rs.3.rs-4769010/v1.
Liang W, Zhou C, Zhang H, Bai J, Jiang B, Jiang C, et al. Recent advances in 3D printing of biodegradable metals for orthopaedic applications. J Biol Eng. 2023;17(1):50. doi:10.1186/s13036-023-00371-7.
Sort J. Special feature: permanent and long-term biodegradable biomaterials. Appl Sci. 2022;12(24):12874. doi:10.3390/app122412874.
Yang H, Lin W, Zheng Y. Advances and perspective on the translational medicine of biodegradable metals. Biomater Transl. 2021;2(3):177-188. doi:10.12336/biomatertransl.2021.03.002.
Shaikh MG, Kahwash F, Lu Z, Alkhreisat M, Mohammad A, Shyha I. Revolutionising orthopaedic implants: a comprehensive review on metal 3D printing with materials, design strategies, manufacturing technologies, and post-process machining advancements. Int J Adv Manuf Technol. 2024;134(3-4):1043-1072. doi:10.1007/s00170-024-14218-y.
Ghazanfari H, Hasanizadeh S, Eskandarinezhad S, Hassani S, Sheibani M, Torkamani AD, et al. Recent progress in materials used towards corrosion protection of Mg and its alloys. J Compos Compd. 2020;2:205-214.
Akbarzadeh F, Sarraf M, Ghomi ER, Kumar VV, Salehi M, Ramakrishna S, et al. A state-of-the-art review on recent advances in the fabrication and characteristics of magnesium-based alloys in biomedical applications. J Magnes Alloys. 2024;12(7):2569-2612. doi:10.1016/j.jma.2024.06.015.
Macêdo TTS, Jesus ILA, Figueredo WN, Dordunoo D. Hypersensitivity reaction to metal: a bibliometric study. SAGE Open Nurs. 2022;8:23779608221132164. doi:10.1177/23779608221132164.
Seetharaman S, Sankaranarayanan D, Gupta M. Magnesium-based temporary implants: potential, current status, applications, and challenges. J Funct Biomater. 2023;14(6):324. doi:10.3390/jfb14060324.
Xu L, Liu X, Sun K, Fu R, Wang G. Corrosion behavior in magnesium-based alloys for biomedical applications. Materials. 2022;15(7):2613. doi:10.3390/ma15072613.
Imani A, Rahimi E, Lekka M, Andreatta F, Magnan M, González-García Y, et al. Albumin protein impact on early-stage in vitro biodegradation of magnesium alloy (WE43). ACS Appl Mater Interfaces. 2024;16(1):1659-1670. doi:10.1021/acsami.3c12381.
Moussa ME, Salem M, Hamid MA, Gomaa MH, Abd-Elwahed AHM, Ghayad IM, et al. Mechanical integrity and in vitro degradation behavior of Mg-Zn-Ca biodegradable alloy prepared by different casting technologies. Int J Metalcast. 2024;18(4):3062-3077. doi:10.1007/s40962-023-01229-w.
Saberi A, Bakhsheshi-Rad HR, Abazari S, Ismail AF, Sharif S, Ramakrishna S, et al. A comprehensive review on surface modifications of biodegradable magnesium-based implant alloy: polymer coatings opportunities and challenges. Coatings. 2021;11(7):747. doi:10.3390/coatings11070747.
Santos-Coquillat A, Martínez-Campos E, Sánchez H, Moreno L, Arrabal R, Mohedano M, et al. Hybrid functionalized coatings on metallic biomaterials for tissue engineering. Surf Coat Technol. 2021;422:127508. doi:10.1016/j.surfcoat.2021.127508.
Almathami S, Venezuela J, Yang N, Wang Y, Mardina Z, Dargusch MS. Exploring the influence of biologically relevant ions on the corrosion behavior of biodegradable zinc in physiological fluids. ACS Biomater Sci Eng. 2023;9(5):2301-2313. doi:10.1021/acsbiomaterials.2c00901.
Salaha ZFM, Abdullah NNAA, Chan KF, Gan H, Yusop MZM, Ramlee MH. Biodegradable orthopaedic implants: a systematic review of in vitro and in vivo evaluations of magnesium, iron, and zinc alloys. Results Eng. 2025;22:105746. doi:10.1016/j.rineng.2025.105746.
Wei S, Ma J, Xu L, Gu X, Ma X. Biodegradable materials for bone defect repair. Mil Med Res. 2020;7(1):54. doi:10.1186/s40779-020-00280-6.
Koushik TM, Miller C, Antunes E. Bone tissue engineering scaffolds: function of multi-material hierarchically structured scaffolds. Adv Healthc Mater. 2022;12(9):2202766. doi:10.1002/adhm.202202766.
Raguraman S, Ulugun B, Ayodeji T, Chowdhury R, Griebel AJ, Weihs TP. Evaluating in-vitro corrosion testing of lean magnesium alloys: the critical role of degradation media composition, buffering, and volume. Res Square. 2024. doi:10.21203/rs.3.rs-5213784/v1.
Cao B, Cao L, Kallmes DF. Degradation rate assessment of biodegradable magnesium alloys. Mater Sci Appl. 2024;15(8):245-256. doi:10.4236/msa.2024.158017.
Ryu H, Seo M, Rogers JA. Bioresorbable metals for biomedical applications: from mechanical components to electronic devices. Adv Healthc Mater. 2021;10(17):2002236. doi:10.1002/adhm.202002236.
Marvi-Mashhadi M, Ali W, Li M, González C, Llorca J. Simulation of corrosion and mechanical degradation of additively manufactured Mg scaffolds in simulated body fluid. J Mech Behav Biomed Mater. 2022;126:104881. doi:10.1016/j.jmbbm.2021.104881.
Ezhilmaran V, Suya Prem Anand P, Kannan S, Sivashanmugam N, Jayakrishna K, Kalusuraman G. Review of bioresorbable AZ91, AZ31 and Mg-Zn-Ca implants and their manufacturing methods. Mater Sci Technol. 2023;39:901-925.
Wang L, He J, Yu J, Arthanari S, Lee H, Zhang H, et al. Degradable magnesium corrosion control for implant applications. Materials. 2022;15(18):6197. doi:10.3390/ma15186197.
Raguraman S, Ulugun B, Ayodeji T, Chowdhury R, Griebel AJ, Weihs TP. Evaluating in-vitro corrosion testing of lean magnesium alloys: the critical role of degradation media composition, buffering, and volume. Res Square. 2024. doi:10.21203/rs.3.rs-5213784/v1.
Koushik TM, Miller C, Antunes E. Bone tissue engineering scaffolds: function of multi-material hierarchically structured scaffolds. Adv Healthc Mater. 2022;12(9):2202766. doi:10.1002/adhm.202202766.
Salaha ZFM, Abdullah NNAA, Chan KF, Gan H, Yusop MZM, Ramlee MH. Biodegradable orthopaedic implants: a systematic review of in vitro and in vivo evaluations of magnesium, iron, and zinc alloys. Results Eng. 2025;22:105746. doi:10.1016/j.rineng.2025.105746.
Liang W, Zhou C, Zhang H, Bai J, Jiang B, Jiang C, et al. Recent advances in 3D printing of biodegradable metals for orthopaedic applications. J Biol Eng. 2023;17(1):50. doi:10.1186/s13036-023-00371-7.
Dargusch MS, Soro N, Demir AG, Venezuela J, Sun Q, Wang Y, et al. Optimising degradation and mechanical performance of additively manufactured biodegradable Fe-Mn scaffolds using design strategies based on triply periodic minimal surfaces. Smart Mater Med. 2024;5:127-138. doi:10.1016/j.smaim.2023.10.003.
Hassan SF, Islam MT, Saheb N, Baig MMA. Magnesium for implants: a review on the effect of alloying elements on biocompatibility and properties. Materials. 2022;15(16):5669. doi:10.3390/ma15165669.
Azadani MN, Zahedi SA, Bowoto OK, Oladapo BI. A review of current challenges and prospects of magnesium and its alloy for bone implant applications. Prog Biomater. 2022;11(1):1-15. doi:10.1007/s40204-022-00182-x.
Kumar R, Mehrotra N, Pal K. Effect of hybrid nano rare earth reinforcement and hot rolling on mechanical, corrosion, and biocompatibility of biodegradable Mg implants. Compos Struct. 2025;349:119657. doi:10.1016/j.compstruct.2025.119657.
Sharma SK, Gajević S, Sharma LK, Pradhan R, Miladinović S, Ašonja A, et al. Magnesium-titanium alloys: a promising solution for biodegradable biomedical implants. Materials. 2024;17(21):5157. doi:10.3390/ma17215157.
Chandra G, Pandey A. Design approaches and challenges for biodegradable bone implants: a review. Expert Rev Med Devices. 2021;18(7):629-646. doi:10.1080/17434440.2021.1935875.
Chen H, Wang Y, He L, Zhang X, Mei Y, Wu T, et al. Surface engineering of biodegradable magnesium alloys as orthopedic implant materials: recent developments and future prospects. Coatings. 2025;15(2):191. doi:10.3390/coatings15020191.
Raguraman S, Ulugun B, Ayodeji T, Chowdhury R, Griebel AJ, Weihs TP. Evaluating in-vitro corrosion testing of lean magnesium alloys: the critical role of degradation media composition, buffering, and volume. Res Square. 2024. doi:10.21203/rs.3.rs-5213784/v1.
Taghipour S, Tahami FV, Allahverdizadeh A. Optimum design of a biodegradable implant for femoral shaft fracture fixation using finite element method. Res Square. 2024. doi:10.21203/rs.3.rs-4769010/v1.
Azadani MN, Zahedi SA, Bowoto OK, Oladapo BI. A review of current challenges and prospects of magnesium and its alloy for bone implant applications. Prog Biomater. 2022;11(1):1-15. doi:10.1007/s40204-022-00182-x.
